肝移植症例登録報告

抄録

As of December 31, 2022, a total of 11,261 liver transplants had been performed in 70 institutions in Japan. There were 804 deceased donor transplants (801 from heart-beating donors and 3 from non-heart-beating donors) and 10,457 living-donor transplants. The annual total of liver transplants in 2022 was 422. Deceased-donor transplants increased to 86 in 2022 from 60 in 2021. The most frequent indication was cholestatic disease, followed by hepatocellular disease and neoplastic disease. As for hepatocellular disease in 2022, alcoholic cirrhosis and non-alcoholic steatohepatitis were the most common. Patient survival following transplantation from heart-beating donors (801 transplants: 1-year 89.4%, 3-year 86.9%, 5-year 83.8%, 10-year 76.2%, 15-year 67.9%, 20-year 54.8%) was similar to that from living-donors (10,457 transplants: 1-year 85.9%, 3-year 82.2%, 5-year 79.7%, 10-year 74.7%, 15-year 69.7%, 20-year 64.9%, 25-year 61.6%, 30-year 58.6%). Graft survival was very much the same as patient survival (heart-beating donor: 1-year 88.9%, 3-year 86.2%, 5-year 83.2%, 10-year 75.6%, 15-year 67.2%, 20-year 54.3%; living-donor: 1-year 85.3%, 3-year 81.2%, 5-year 78.6%, 10-year 73.0%, 15-year 67.5%, 20-year 62.3%, 25-year 58.9%, 30-year 56.0%). Survival data are reported according to age and sex of recipient, indication, graft type, age and sex of donor, ABO-compatibility, and other factors. Cause of death of living liver donors is also reported.