Current clinical evidence of normothermic and oxygenated hypothermic machine perfusion in kidney grafts
2023 年 58 巻 Supplement 号 p. s125_2
詳細
2023 年 58 巻 Supplement 号 p. s125_2
The use of high-risk kidney grafts for transplantation requires optimization of pre-transplant evaluation and preservation reconditioning strategies to reduce organ discard rates and improve short- and long-term clinical outcomes.
It is becoming further recognized that active oxygenation plays a central role in dynamic preservation strategies that realign mitochondria and restore cellular energy profiles, regardless of storage temperature. Reducing oxygen-related mitochondrial succinic acid accumulation improves the harmful effects of ischemia-reperfusion injury.
The difference between normothermic and hypothermic machine perfusion with respect to organ evaluation, preservation and reconditioning, as well as logistics and economic implications, are factors to be considered in each clinical field. Therefore, these various techniques should be considered as complementary to the perfusion strategies that are selected according to functional intention and resource availability.
In this symposium, we would like to present an overview of the current clinical evidence for normothermic and oxygenated hypothermic machine perfusion either as a continuous or end-ischemic preservation strategy.
