Abstract
The relation between brain atrophy and P300 latency studied by computed tomography was evaluated in 19 nondemented patients with cerebral infarcts in the territory of the deep perforators of the internal carotid artery system. Brain atrophy was quantitatively measured on CT images by two-dimensional measurement of brain areas as shown in Figure 1, and ventricular area index (VAI) and brain atrophy index (BAI) were calculated. VAI increased and BAI decreased significantly with advancing age (Figure 2). It clearly demonstrated that P300 latency significantly increased with advancing age (Figure 3). There was a significant correlation between brain atrophy and P300 latency (Figure 4).
These results indicate that there is a close correlation between brain atrophy and mild intellectual impairment in the nondemented lacunar stroke patients.
