Abstract
We examined the efficacy of intravenous sodium ozagrel, a selective thromboxane A2 synthetase inhibitor, and heparin in elderly patients with acute thrombotic and hemodynamic stroke. A total of 84 consecutive patients admitted within 72 hours from the onset of symptoms were allocated randomly into 3 groups. Forty-seven cases were treated with intravenous sodium ozagrel and heparin (OH group), 16 cases underwent only sodium ozagrel administration (O group) and 21 cases received only glycerol (G group). The neurological scores improved significantly in the OH group as compared to the O group (p< 0.05) and G group (p <0.01) over the first 3 and 7 days. Hemorrhagic complications including hemorrhagic infarction were not observed in both the OH group and O group. We conclude that combined therapy with intravenous sodium ozagrel and heparin was more effective than their sole administration for acute thrombotic and hemodynamic cerebral ischemia in aged patients.
