Abstract
To avoid influenza virus infection, antibodies that inhibit influenza virus propagation should be elicited by vaccination. Because the hemagglutination-inhibition titer is considered as an immunological correlate of protection against influenza virus infection, most of the current vaccines target the induction of such antibodies. Recent studies on human monoclonal antibodies have revealed the multiple mechanisms of virus growth inhibition by human antibodies against various virus proteins. One of the most attractive findings is protective antibodies against viral NA protein. Here, we would like to summarize the basic information of NA protein, suppression of virus propagation by anti-NA antibodies, and improvement of the current inactivated influenza vaccine.
