牛血清γ-グロブリンによる急性灰白髄炎の予防及び治療に関する基礎的実験

抄録

Normal cow serum gamma globulin (exactly, γ-globulin and β-globulin fraction) was fractionated by the low temperature ethanol method. Experiments on the control and treatment of poliomyelitis infection (of Lansing strain) was carried out, using mouse as experimental animal. The results were as follows.
Gamma globulin of normal cow serum was effective, when administered for the purpose of the prevention of the disease.
The influence or effectivity of γ-globulin administration depends largely on the quantitative difference of the titers of the neutralizing antibody against the virus.
To start γ-globulin administration shortly before the virus challenge seems to be most effective to satisfy the preventive purpose.
As for the treatment after the virus invasion, the mouse group which had been passively immunized with γ-globulin before the time of the virus challenge was divided into two groups, one of which had received the second treatment of γ-globulin, while the other group did not. The group that had the second treatment showed the prolongation of the incubation period and also the decrease in mortality, compared with the other group and the non-treated group. Based on the present experiment, it may be said that not only the prevention but also the therapy of poliomyelitis infection is not without hope, if adequate γ-globulin is properly administered.