Abstract
De Meio and Walker were the first who recognized the antibody elevation against Sendai virus with mumps infections. The work to be reported here was conducted one to confirm their results and another to test the usefulness of soluble antigens of respective virus in serodiagnosis, in an effort to differentiate these two kind of infections.
The results obtained so far will be summarized as follows:
1) From 19 mumps children living in Sendai, paired serum specimens were obtained and tested for their antibody titer by means of hemagglutination inhibition (HAT) and complement fixation tests (CFT) with both viral and soluble antigens of respective virus. Antibody elevation in HAI as well as in CFT-V and-S was evident with all of these pairs, when mumps virus (Habel strain) was used as antigen.
2) When these paired specimens were tested with antigens of Sendai virus, significant elevation of HAI titer was shown with 7 pairs (37%). However total 13 pairs among 19 (68%) revealed the positive HAI titer against Sendai virus including the pairs with a little or no elevation. The fact may suggest the possibility that mumps virus antigen is highly related to that of Sendai virus, particularly in HAI test. The fact that even in acute phase, some patients revealed HAI antibody titer against Sendai virus comparative to or higher than the titer against mumps virus was the main interest here evoked. Parallel elevation against heterologus antigen here pointed out, however, did not hold true with all of the tested pairs. Elucidation of this fact was left in a future.
3) With complement fixation test using antigens derived from Sendai virus, some cross reaction was also observed at least when V antigen was used. But the correlation rate with mumps antigen was rather low when compared to the result obtained in HAT test.
4) Any specimens examined here did not reveal antibody titer against soluble antigen of Sendai virus. This fact was thought to be useful, in differentiating mumps patients from infection of Sendai virus.
