抄録
Comparative investigations were carried out, on the development of neutralizing antibody (VN antibody), hemagglutination inhibiting antibody (HI antibody) and complement fixing antibody (CF antibody) in experimental animals inoculated with the ectromelia virus.
Results were as follows.
1. In mice inoculated with the ectromelia virus, the development of VN antibody, HI antibody and CF antibody against ectromelia and vaccinia viruses were recognized.
2. In guinea pigs inoculated with the ectromelia virus, the constant development of HI antibody against ectromelia virus was recognized. Although the development of CF antibody was recognized, too, it was not so regular as in HI antibody and the individual differences were seen.
On VN antibody, even in the guinea pigs inoculated repeatedly with the ectromelia virus in large quantities it was considered that the neutralizing capacity of anti-serum against ectromelia virus existed within the limit of experimental error. And so, it was thought that there was little development of VN antibody in guinea pigs.
3. In rabbits inoculated repeatedly with the ectromelia virus in large quantities it was shown that the neutralizing capacity of immune serum against ectromelia virus was presented within the limit of experimental error. And so, it was thought that there was little development of VN antibody in rabbits like in guinea pigs. Also, the development of HI antibody and CF antibody against ectromelia virus was not observed. Although in the serum of these rabbits immunized with the ectromelia virus there was no significant production of HI, CF and VN antibodies against ectromelia virus, all of three antibodies against vaccinia virus were shown. The reason of this phenomenon was briefly discussed.
