Abstract
The authors' virus watch program on an infant asylum in Toyama City revealed that adenoirus type 1 (Adv. 1) was prevailing in the population over a period from May, 1966, to June, 1968. Each individual was examined quantitatively for antibodies against Adv. 1 (NT and HI) in relation to virus isolation from feces. The following results were obtained.
1. A systematic pursuit was required for the study of Adv. 1 infection on virus isolation from feces and antibody contents in serum in each individual. In many cases, Adv. 1 was excreted intermittently. No significant antibody reponse was observed over a period from 2 to 4 months after the first virus isolation.
2. No antibodies in serum seemed to affect Adv. 1 in feces. The infectivity of Adv. 1 in fecal specimens to HeLa S3 cell culture was low, but remained unchanged even after antibodies against Adv. 1 were detectable in serum.
3. HEK cells exhibited a higher susceptibility to Adv. 1 than HEL and HeLa S3 cells, which became as susceptible to Adv. 1 as HEK cells after 2-3 blind passages. Hep-2 cells were less susceptible to the same virus than any of the three types of cells.
4. No significant clinical signs were manifested even by children excreting Adv. 1 intermittently for a long period of time.
