Abstract
In the previous report, an exploratory experiment to ascertain the presence or absence of similar modifying effect of bacteria or bacterial substances on the course of neurotropic virus infection to that of preumotropic virus in the natural state has been studied. The results obtained indicated that there are some bacteria having the inhibitory or stimulating effect on the virus infection.
The purpose of this paper is to report the mode and mechanism of the effect of E. coli which is selected among the bacteria having the inhibitory effect on the virus infection in an exporatory experiment. From the results obtained, it seems probable that the effect inhibits the connection with the virus and host cells from reasons of the following: the effect of E. coli is significant when the bacteria is given to mice two days before the virus inoculation; the most evident effect is obtained at the same route of virus and bacteria inoculation; the bacteria possess no direct virucidal activity; the anti-E. coli-serum is not related with the virucidal activity and virus neutralization; and both infection protecting activity and neutralizing antibody in the survival mice is not recognized. The effect of E. coli exists in the cells and thermostabile.
