抄録
Various mutagens and carcinogens are formed during the chlorine disinfection of raw drinking water. Among them, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), exhibits a high mutagenic activity against Salmonella typhimurium TA100 without S9 mix, which is comparable to aflatoxin B1. Recently, it has been demonstrated that MX induces stomach tumor to rats in the 2-stage carcinogenicity test using N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). In this review, we summarize the distribution of MX in several water samples including drinking water and its chemical, biological and genotoxic properties.
