Abstract
Medicinal value of Withania somnifera Dunal (Ashwagandha) extends from anti-inflammatory, antiseptic, anti-stress, anti-arthritic, anti-rheumatic, anti-bronchitis, immuno- and appetite- stimulator to promote overall memory, rejuvenation, vitality, endurance, stamina and longevity. However, the molecular biology of myriads of these anti-disease or health-promoting effects remains insufficiently explored to date. We earlier reported that the Leaf extract from Ashwagandha (Lash) has selective anticancer activity that operates through the activation of p53 tumor suppressor pathway. Here we report that the selective killing activity of Lash can be employed in combination with anticancer drugs to yield an effective combinatorial anticancer formulation.
