TISSUE CULTURE RESEARCH COMMUNICATIONS
Online ISSN : 1881-3704
Print ISSN : 0912-3636
ISSN-L : 0912-3636
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REVIEW
  • Mechanism and significance of gene expression alteration in phagocytes upon engulfment of apoptotic cells
    Saori Nonaka, Akiko Shiratsuchi
    Article type: REVIEW
    2024 Volume 42 Issue 1 Pages 1-7
    Published: 2024
    Released on J-STAGE: January 19, 2024
    DOIhttps://doi.org/10.11418/jtca.42.1
    JOURNAL FREE ACCESS FULL-TEXT HTML
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    In our bodies, tens of billions of unnecessary cells appear every day, and these cells are induced to undergo apoptosis, engulfed, and digested by phagocytes such as macrophages. This process is required for tissue homeostasis, and evolutionally conserved among multicellular organisms. Although the role of phagocytosis of apoptotic cells has been thought to be the physical removal of unnecessary cells, recent studies showed that phagocytes change their function upon engulfment of apoptotic cells, accompanied by alteration of gene expression. This review describes the molecular mechanisms and significance of such a novel biological event, focusing on the authors’ studies using fruit fly Drosophila.

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