抄録
Androgen-unresponsive cancer cells were established from androgen-dependent tumor, and role of androgen receptor (AR) in these cells was studied. Next, in human prostatic cancer at untreated and endocrine therapy-resistant stages structure of AR were examined. From the results, Following classification on relationship between changes of AR and loss of response is proposed; a) loss of AR is the causal event. This type of response to androgen was found in rat prostatic cancer cell line. b) loss of AR is not required on progression to unresponsive tumor. This type was found in a mouse mammary tumor cell line. c) abnormal AR accompanying with loss or change of response to androgen. This type was found in human prostatic cancer tissues. It is indicated that loss of response to androgen occurs through many ways; some of which may require change of AR, the other is independent on state of AR.
