We measured the contents of minerals in liver, brain and serum of rats after the continuous administration of oyster’s extract. Many minerals were the increasing trend after the chronic administration of oyster’s extract, and the content of lithium in brain was about eight times higher than normal group. The contents of tryptophan, 5-hydroxytryptamine and 5-hydroxy-indole acetic acid in brain were increased by tryptophan loading in the rats administrated lithium chronically. And, they were increased by tryptophan loading in the rats administrated oyster’s extract chronically, too.
