メチオニンとセレン欠乏ラットにおけるセレンとセレン関連酵素の変化について

抄録

Studies were perfeormed to clarify the effects of methionine and/ or selenium deficiency and different forms of selenium (sodium selenate and selenomethionine) on selenium metabolism and the enzymatic activities of type I iodothyronine 5’deiodinase and glutathione peroxidase, Fourty-two weanling male Wistar rats were divided into six groups and pairing fed the respective diets for 4 wk. The results showed that methionine-deficiency interfered with selenate absorption which induced lower selenium con- centration, type I 5’ deiodinase and glutathione peroxidase activities in liver whereas did not affect selenomethionine absorption. Glutathione of liver was decreased in methionine-deficiency which may account for the lower absorption of selenate in methionine-deficiency. Selenium concentrations and activities of type I 5’ deiodinase and glutathione peroxidase were decreased in selenium-deficiency. It is suggested that methionine-deficiency diminishes selenoenzymatic activities not only glutathione peroxidase but type I 5’deiodinase which may be due to the bad absorption or availability of seleuium.