視床下部-下垂体-副腎皮質系に対する酸性線維芽細胞成長因子の作用

抄録

Effects of acidic fibroblast growth factor (aFGF) on the hypothalamo pituitary-adrenocortical axis were examined in anethetized rats. Intracerebroventricular (i.c.v.) and intravenous (i.v.) injections of aFGF increased the level of plasma corticosterone. Pretreatment of i.c.v. anti-CRF antibody abolished the increase of plasma corticosterone level induced by i.c.v. aFGF injection, but had no effect on that elicited by i.v. aFGF injection. The plasma ACTH level was increased by i.v. aFGF injection. The results indicate that centrally and peripherally applied aFGF activates the adrenocortical system via the CRF release and the ACTH release, respectively.