亜鉛と生体反応 -特に炎症反応とc-fosの発現について-

抄録

The present study was designed to examine if zinc (Zn) affects the development of unilateral ureteral obstruction (UUO)-induced tutbulointerstitial nephropathy and the expression of the proto-oncogene, c-fos mRNA relating to the induction of apotosis and carcinogenesis. Compared to rats fed a standard or a high Zn diet, rats fed a Zn deficiency diet showed a more influx of leukocytes into the interstitium and m part had the structural damage of glomeruli in the cortex of the obstructed kidney at day 3 following UUO. These histological changes, however, were ameliorated by administration of enalapril, an angiotensin (ANG) I converting enzyme inhibitor. Again. the expression of c-fos mRNA was observed only in the kidney of rats fed a Zn deficiency diet. Thus, it is suggested that Zn deficiency not only aggravates UUO-induced tubulointerstitial nephropathy via an increase in the action of ANG II but also enhances the expression of c-fos mRN A in the kidney.