ジピコリン酸による銅イオン依存性酸化傷害の防御機構

抄録

Protective effects of dipicolinic acid (pyridine 2,6-dicarboxylic acid) on copper-dependent LDL oxidation and DNA strand breaks were analyzed in relation to the inhibition of the copper reduction. Dipicolinic acid inhibited the copper-mediated oxidation of low density lipoprotein, whereas other pyridine carboxylates showed only a little protective action. Dipicolinic acid further exhibited the copper-dependent DNA strand breaks. Dipicolinic acid showed a potent inhibitory activity against copper reduction by LDL itself and gallic acid. Protection by dipicolinic acid against copper-dependent injuries of LDL and DNA can be explained by the inhibition of copper reduction, that is the formation of cuprous ion the prooxidant.