The determination of urine protein and creatinine concentrations in the urine of HIGA mice and BALB/c mice after subacute administration of fluoride via their drinking water

抄録

Fluoride (F) widely exists in nature and is contained in food and water. One of the target organs of F is the kidney. High IgA (HIGA) mice have been used as a model of IgA nephropathy. The objective of this study was to get information for the alterations in the renal function of HIGA mice exposed to F. The HIGA and BALB/c mice were exposed to F at 0, 50, 100, and 150 ppm in their drinking water for 4 weeks. For the protein levels in the urine, the mean of the 100-ppm group of HIGA mice after 3 weeks from the beginning of the exposure was significantly higher than those in the 0- and 50-ppm groups. For BALB/c mice, the mean protein level in the 100-ppm group was significantly higher than those in the 0- and 50-ppm groups after 2 weeks. The mean creatinine in the urine in the 50-, 100-, and 150-ppm groups of HIGA mice were significantly lower than that in the 0-ppm group after 4 weeks. For BALB/c mice, the mean creatinine in the 50-, 100-, and 150-ppm groups were significantly lower than that in the 0-ppm group after 2 weeks. The exposure to F at 100 ppm may induce temporal toxicity to the kidneys of mice, but no differences of toxic effects of F between the 11- to 12-week-old HIGA and BALB/c mice were observed.