プロシーディング
Mineral Metabolism in a Patient Receiving Long Term Total Parenteral Nutrition
1987 年 4 巻 p. 103-107
詳細
1987 年 4 巻 p. 103-107
A male patient, 61 years old, was received the total resection of small intestine and colon with jejunostomy. The patient has been treated by total parenteral nutrition (TPN) immediately after the operation. The mineral (Se, Zn and Cu) metabolism in this patient was examined.
At around 7 months after TPN, the Se concentrations in whole blood (53 μg/ml) and plasma (34 μg/ml) as well as urinary Se losses (10 μg/day) were remarkably decreased.
Under these lower Se conditions, sodium selenite (0.1mg-Se/day) was administered from 283 to 360 days on TPN, and also blood was transfused twice during this period.
The Se concentrations in whole blood and plasma, but not red blood cells (RBC), and the urinary Se excretion increased immediately after Se infusion. After the blood transfusion, the Se concentrations in whole blood, plasma and RBC, and urinary Se excretion markedly increased. However, RBC glutathione peroxidase activity was not affected by Se infusion.
