Effect of Dietary Xenobiotics on the Metabolism of Trace Elements in Rats

抄録

Exeriments were conducted with growing male rats to study effects of dietary addition of PCB and some other xenobiotics on tissue levels of essential trace elements; iron, zinc, copper, manganese, molybdenum, chromium, nickel, and cobalt. The animals were fed ad libitum the test diets containing xenobiotics for 14 to 15 days. Analysis of the elements was performed using a polarized Zeeman atomic absorption spectrophotometer. Dietary addition of 0.02% or 0.05% PCB significantly raised liver concentration of copper. Other elements in liver were not markedly influenced by PCB intake. Kidney and serum levels of copper were also found to be increased by PCB. Dietary addition of other xenobiotics such as 0.3% caffein, 0.05% DDT, 0.3% flavone, 0.3% chloretone, and 0.3% BHA also caused an incrase in tissue copper. In general, serum copper was correlated with serum cholesterol in these dietary manipulation.