低蛋白食摂取ラットにおけるビタミンE栄養状態

抄録

Protein-calorie malnutrition is still a serious problem in developing countries. It is well-known that low-protein diet causes deficiency of trace nutrients. But the influence of low-protein diet on vitamin E status is not completely clear yet.

We studied the influence of low-protein diet on vitamin E status using male Wistar 3 week-old rats. The rats were devided into 3 groups: group 1; 5% casein, group 2; 10% casein, group 3 ( control group); 20% casein. They were fed ad libitum for 6 weeks. Tocopherols in plasma, liver, kidney, brain, spleen and testis were measured by HPLC-fluorometric method.

α-Tocopherol concentration in liver, kidney and plasma of rats fed 5% casein diet were significantly low compared with those of rats fed 20% casein diet. α-Tocopherol in liver and kidney of rats fed 10% casein diet were also significantly low compared with those of rats fed 20% casein diet. A uniform relationship between β, γ-Tocopherols concentrations in tissues and protein concentration in diet was not found.

The results in this study suggest that protein-mulnutrition at growing age influences vitamin E status.