マグネシウム欠乏ラットにおける体内マンガン及び肝臓中ピルビン酸カルボキシラーゼ活性の変化

抄録

Wistar male rats were divided into two groups. To one group magnesium deficient diet was given and to the other group magnesium sufficient diet was given for 2 weeks. The biochemical properties of pyruvate carboxylase in crude rat liver mitochondria fractions were investigated with the method of the spectrophotometrical assay. The significant changes seen in magnesium deficient rats were as follows Pyruvate carboxylase acitivity in liver crude mitcondrial fraction of magnesium deficient rats was decreased and manganese concentration was decreased in plasma and all tissues except blood. Positive correlation between pyruvate carboxylase activity and manganese concentration in liver was found. Magnesium concentration was decreased in brain, spinal cord, lung, spleen, kidney, testis, bone, blood and plasma, and was increased in liver.