The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Regular Paper
FOUR-WEEK ORAL TOXICITY STUDY OF 1-CARBOXY-5,7-DIBROMO-6-HYDROXY-2,3,4-TRICHLOROXANTHONE (HXCA), AN IMPURITY OF PHLOXINE B, IN F344 RATS
Akihiro HAGIWARAMasashi SANOToshio ICHIHARAHiroko YOSHINOEmiko MIYATASeiko TAMANOHiromitsu AOKIChiyoki YUKAWATakatoshi KODAMikio NAKAMURATomoyuki SHIRAI
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2003 Volume 28 Issue 5 Pages 445-453

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Abstract

This study was designed to evaluate and characterize any subacute toxicity of 1-carboxy-5,7-dibromo-6-hydroxy-2,3,4-trichloroxanthone (HXCA), an impurity of Phloxine B (Food Red No. 104 in Japan, D&C Red No. 28 in the USA), when administered to both sexes of F344 rats at dietary levels of 0 (control), 0.005, 0.05 and 0.5%. During the study, the treatment had no effects on clinical signs, survival, urinalysis or ophthalmology. Hematology, blood biochemistry, gross pathology, organ weights, organ to body weight ratios and histopathology exhibited no differences of toxicological significance between control and treated rats. Reactions to treatment may be summarized as follows: there was a tendency for increased food and water consumption and decreased food efficiency in both sexes of the 0.5% group. Thus, these results indicated the no-observed-adverse-effect level (NOAEL) of HXCA to be 0.05% (39.3 mg/kg/day for males, and 41.0 mg/kg/day for females).

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© 2003 The Japanese Society of Toxicology
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