The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Review
Nrf2-DEPENDENT GENE EXPRESSIONS: A MOLECULAR TOXICOLOGICAL ASPECT
Satoshi NUMAZAWATakemi YOSHIDA
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2004 Volume 29 Issue 2 Pages 81-89

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Abstract

Although NF-E2 related factor 2 (Nrf2) was found to be a transcriptional regulator that controls an expression of the β-globin gene, the notion is now widely accepted that this transfactor serves as a master regulator for the gene expression of a battery of proteins acting on anti-oxidative stress and detoxification of electrophiles. The function of Nrf2 that bears transcriptional activation depends solely on its nuclear localization, which is regulated by interaction with the cytosolic anchor protein Keap1 and its own turnover rate. In the present mini-review, we focus on the regulation of Nrf2 function and discuss the physiological and toxicological aspects of this transcriptional factor.

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© 2004 The Japanese Society of Toxicology
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