The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Letter
CISPLATIN (CDDP)-INDUCED ACUTE TOXICITY IN AN EXPERIMENTAL MODEL OF HEPATIC FIBROSIS
Yohei MIYAMOTOKaoru SHIMADAYuka SAKAGUCHIMari MIYAMOTO
Author information
JOURNALS FREE ACCESS

2007 Volume 32 Issue 3 Pages 311-319

Details
Abstract

Cisplatin (CDDP)-induced acute toxicity was investigated in an experimental model of liver fibrosis produced through repeated intraperitoneal injections of swine serum in rats. A significant increase in level of hepatic markers, such as plasma ASAT, LDH, glucose, total cholesterol and bile acid levels, and a significant decrease in the plasma triacylglycerol level were observed. Slight histological changes, such as necrosis, vacuolar degeneration, and the proliferation of bile ducts were observed as compared with the control fibrotic rats. On the other hand, a significant increase in levels of renal markers, such as plasma BUN and creatinine levels as well as more remarkable tubular degeneration were observed. From these results, CDDP's hepatotoxicity was slight while its nephrotoxicity was more extensive in fibrotic rats.

Information related to the author
© 2007 The Japanese Society of Toxicology
Previous article Next article
feedback
Top