The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Letter
TOXICITY SCREENING AFTER REPEATED DOSE OF A NEWLY DEVELOPED ORAL HEPARIN DERIVATIVE IN MALE CYNOMOLGUS MONKEYS
Choong-Yong KIMJeeEun KIMKangHyun HANSangKyoon KIMKuiLea PARKYoungro BYUN
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2007 Volume 32 Issue 4 Pages 411-420

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Abstract

Toxicity screening of a newly developed oral heparin derivative was carried out in twelve male cynomolgus monkeys (Macaca fascicularis), composed of three treatment and vehicle control groups. A newly orally active heparin derivative, developed by Seoul National University, was given to the treatment group at three doses with low (12.8 mg/kg), medium (89.6 mg/kg) and high (640 mg/kg) doses for 14 days. A treatment group did not show any change in body weights, hematological parmeters (e.g., RBC, WBC, platelet, PDW, MPV, etc.) and serum biochemical parameters (e.g., AST, ALT, BUN, etc.) for 2 weeks compared with those of the vehicle control group. These findings indicated that the oral anticoagulant drug, a newly developed oral heparin derivative, did not have any toxic effect for 2 week in this study. The present study will be valuable in the proper interpretation for non-clinical study using cynomolgus monkeys in the development of a new drug of heparin derivative.

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© 2007 The Japanese Society of Toxicology
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