The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Letter
THIRTEEN-WEEK REPEATED DOSE ORAL TOXICITY STUDY OF COENZYME Q10 IN RATS
Kumiko HONDASayumi TOMINAGATakafumi OSHIKATAKouichi KAMIYAMasao HAMAMURATsuneshirou KAWASAKIKouichi WAKIGAWA
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2007 Volume 32 Issue 4 Pages 437-448

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Abstract

As part of a safety evaluation of Coenzyme Q10, a subchronic toxicology study was conducted. Coenzyme Q10 was repeatedly administered orally to male and female Crl:CD(SD) rats at daily dose levels of 300, 600 and 1200 mg/kg for 13 weeks. Neither death nor any toxicological signs were observed in any group during the administration period. No change related to the test substance administered was observed in any group with regard to body weight, food consumption, ophthalmoscopy, hematology, blood biochemistry, necropsy, organ weights or histopathology. Based on these results, the non-observed-adverse-effect level (NOAEL) of Coenzyme Q10 was considered to be 1200 mg/kg/day for male and female rats under these study conditions.

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© 2007 The Japanese Society of Toxicology
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