siRNA-MEDIATED INHIBITION OF PHOSPHATIDYLINOSITOL GLYCAN CLASS B (PIGB) CONFERS RESISTANCE TO METHYLMERCURY IN HEK293 CELLS

Gi-Wook HWANG; Tatsuya HAYASHI; Kayoko KITA; Tsutomu TAKAHASHI; Shusuke KUGE; Akira NAGANUMA

doi:10.2131/jts.32.581

Toxicogenomics/proteomics Report

siRNA-MEDIATED INHIBITION OF PHOSPHATIDYLINOSITOL GLYCAN CLASS B (PIGB) CONFERS RESISTANCE TO METHYLMERCURY IN HEK293 CELLS

Gi-Wook HWANG, Tatsuya HAYASHI, Kayoko KITA, Tsutomu TAKAHASHI, Shusuke KUGE, Akira NAGANUMA

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JOURNAL FREE ACCESS

2007 Volume 32 Issue 5 Pages 581-583

DOI https://doi.org/10.2131/jts.32.581

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Abstract

We performed functional gene screening, using a siRNA library targeting 8,500 human genes, to identify proteins that are involved in the susceptibility of cells to methylmercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.

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