The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Original Article
Toenail selenium levels and gastric cancer risk in Cali, Colombia
Chihaya KoriyamaFrancia I. CamposMegumi YamamotoMauricio SerraGabriel CarrasquillaEdwin CarrascalSuminori Akiba
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JOURNALS FREE ACCESS

2008 Volume 33 Issue 2 Pages 227-235

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Abstract

To examine an association between selenium level and gastric cancer (GC) risk, a hospital-based case-control study was conducted in Cali, Colombia. Selenium concentrations in toenails were compared between 142 GC patients and 244 controls selected from hospitalized non-cancer patients. GC risk was lowest in the lowest quartile of selenium level and highest in the second highest quartile (age-, sex-, hospital-, and sampling-season-adjusted odds ratio [OR]: 5.9, 95% confidence interval: 2.8, 12.4). This association was not modified by either tumor location or Lauren's histological type. The magnitude of ORs was not affected by other diets that were significantly associated with GC risk. Since selenium levels were relatively high in cases and in controls, our results indicate that an inverse association between selenium level and GC risk may exist only among populations with low selenium levels.

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© 2008 The Japanese Society of Toxicology
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