DNA microarray analysis of genomic responses of yeast Saccharomyces cerevisiae to nickel chloride

Shota Takumi; Hirokazu Kimura; Hiromi Matsusaki; Sadahiro Kawazoe; Nobuaki Tominaga; Koji Arizono

doi:10.2131/jts.35.125

Toxicogenomics/proteomics Report

DNA microarray analysis of genomic responses of yeast Saccharomyces cerevisiae to nickel chloride

Shota Takumi, Hirokazu Kimura, Hiromi Matsusaki, Sadahiro Kawazoe, Nobuaki Tominaga, Koji Arizono

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Keywords: Nickel chloride, Sacchromyces cerevisiae, DNA microarray

JOURNAL FREE ACCESS

2010 Volume 35 Issue 1 Pages 125-129

DOI https://doi.org/10.2131/jts.35.125

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Abstract

In order to investigate nickel toxicity against the yeast Saccharomyces cerevisiae, genomic responses to nickel chloride were examined using yeast DNA microarrays. Microarray analysis revealed that exposure to 25 mM nickel chloride for 2 hr induced changes in gene expression in S. cerevisiae. Nickel chloride increased expression levels in 601 genes and decreased expression levels in 696 genes in S. cerevisiae.

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