The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Toxicogenomics/proteomics Report
Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor α (PPARα) stimulation
Masafumi MiyazakiIppei NakagawaShigeru KogaYasushi KasaharaMatthew P. Patricelli
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JOURNALS FREE ACCESS

2010 Volume 35 Issue 1 Pages 131-135

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Abstract

To investigate peroxisomal proliferator-activated receptor α (PPARα) signal responses in heart muscle, we performed LC-MS/MS-based proteomics analysis of heart muscle from rats given fenofibrate or clofibrate. Fenofibrate increased the expression of ACAA2, DECR1, and ECH1 consistent with activation of PPARα. Fenofibrate and clofibrate reduced the expression of 10 and 12 proteins, respectively with the expression of ACSL1, SLC25A4, A1BG, HADHA, ATP2A2, BDH1, ETFDH, HADHB, and CPT2 being reduced in common with both of fibrate-treated groups. The approach adopted in this study provides an efficient method for monitoring global changes in protein expression.

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© 2010 The Japanese Society of Toxicology
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