The Journal of Toxicological Sciences
Toxicogenomics/proteomics Report
siRNA-mediated AMPKα1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells
Gi-Wook HwangMayumi TobitaTsutomu TakahashiShusuke KugeKayoko KitaAkira Naganuma
Author information
JOURNALS FREE ACCESS

Volume 35 (2010) Issue 4 Pages 601-604

Details
Download PDF (173K) Contact us
Abstract

The environmental pollutant methylmercury is a potent neurotoxin. The mechanisms of toxicity and biological defense remain largely unknown. We found that inhibiting the expression of PRKAA1 (AMPKα1), an activated subunit of AMP-activated protein kinase (AMPK), increased susceptibility of HEK293 cells to methylmercury toxicity. Treatment of the cells with AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside), an AMPK activator, reduced the methylmercury toxicity. Here, we suggest for the first time that the activation (phosphorylation) of AMPK may play an important role in reducing the toxicity of methylmercury.

Information related to the author
© 2010 The Japanese Society of Toxicology
Previous article Next article

Recently visited articles
feedback
Top