The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice
Yuta TakahashiKeisuke MizuoYusuke ShinkaiShigeru OshioKen Takeda
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2010 Volume 35 Issue 5 Pages 749-756


Titanium dioxide (TiO2) nanoparticles are widely used in cosmetics, sunscreen and as a photocatalyst. However, little is known about the biological effect of TiO2 nanoparticles in humans and other animals. Here, we investigated whether prenatal exposure to TiO2 nanoparticles impacted the central nervous system in mice. We measured the levels of dopamine (DA) and its metabolites in several regions of the brain in mice using high performance liquid chromatography (HPLC). HPLC analysis showed that DA and its metabolites were increased in the prefrontal cortex and the neostriatum following prenatal exposure to TiO2 nanoparticles. The present study highlights the possibility that maternal exposure to TiO2 nanoparticles might influence the development of the central dopaminergic system in offspring.

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© 2010 The Japanese Society of Toxicology
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