The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Letter
Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe
Koichi AkiyamaTomoko IwakiNaoko SugimotoSoracom ChardwiriyapreechaMiyuki KawanoSogo NishimotoTakuya SugaharaTakayuki SekitoYoshimi Kakinuma
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2011 Volume 36 Issue 1 Pages 117-120

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Abstract

ATP-binding cassette (ABC) transporter plays an important role for resistance against xenobiotics. There are eleven ABC transporter genes in the genome of fission yeast Schizosaccharomyces pombe. We examined the role of ABC transporter against the toxicity of tributyltin chloride (TBT), a widespread environmental pollutant, in cell growth. Among individual ABC transporter mutants, the growth of a mutant deficient in Bfr1p, a plasma membrane-embedded transporter, was extremely sensitive to TBT. The lethal TBT concentration inducing 50% of cell death (LC50) was 25 µM for the parent strain and 10.2 µM for the bfr1∆ mutant. Thus, Bfr1p was responsible for TBT resistance in S. pombe.

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© 2011 The Japanese Society of Toxicology
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