DNA microarray analysis of normal rat kidney epithelial cells treated with cadmium

Maki Tokumoto; Tomoaki Ohtsu; Akiko Honda; Yasuyuki Fujiwara; Hisamitsu Nagase; Masahiko Satoh

doi:10.2131/jts.36.127

Toxicogenomics/proteomics Report

DNA microarray analysis of normal rat kidney epithelial cells treated with cadmium

Maki Tokumoto, Tomoaki Ohtsu, Akiko Honda, Yasuyuki Fujiwara, Hisamitsu Nagase, Masahiko Satoh

Author information

Keywords: Cadmium, Renal toxicity, DNA microarray

JOURNAL FREE ACCESS

2011 Volume 36 Issue 1 Pages 127-129

DOI https://doi.org/10.2131/jts.36.127

Details

Abstract

In order to elucidate the transcriptional response of kidney epithelial cells to cadmium, the gene expression pattern was examined in normal rat kidney epithelial cells (NRK-52E cells) exposed to 50 µM cadmium for 4 hr using DNA microarray. Cadmium was found to increase the expression of 73 genes and decrease the expression of 42 genes in NRK-52E cells before the development of cytotoxicity.

Corresponding author

Register with J-STAGE for free!