Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells

Gi-Wook Hwang; Ke Du; Tsutomu Takahashi; Akira Naganuma

doi:10.2131/jts.36.847

Toxicogenomics/proteomics Report

Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells

Gi-Wook Hwang, Ke Du, Tsutomu Takahashi, Akira Naganuma

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Keywords: Cadmium, Ubiquitin ligase, F-box protein, FBXO6

JOURNAL FREE ACCESS

2011 Volume 36 Issue 6 Pages 847-849

DOI https://doi.org/10.2131/jts.36.847

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Abstract

Cadmium is a typical environmental pollutant and the causative agent of itai-itai disease. Ubiquitin ligases potentially involved in mediating the effects of cadmium toxicity were investigated by RNA interference using a panel of small inhibitory (si)RNAs. The results demonstrated that the inhibition of gene expression of FBXO6 sensitizes HEK293 cells to cadmium.

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