The Journal of Toxicological Sciences
Toxicogenomics/proteomics Report
Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae
Tsutomu TakahashiShingo NakashimaTakuro MasudaShigehiro YonedaGi-Wook HwangAkira Naganuma
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Volume 36 (2011) Issue 6 Pages 855-857

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Abstract

To elucidate the mechanisms underlying adriamycin resistance, adriamycin resistance-related genes were explored using the budding yeast Saccharomyces cerevisiae as a useful eukaryotic model. The CLN1 and CLN2 genes, encoding G1 cyclin, and the ERG13 gene, encoding 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase, were identified.

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© 2011 The Japanese Society of Toxicology
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