Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae

Tsutomu Takahashi; Shingo Nakashima; Takuro Masuda; Shigehiro Yoneda; Gi-Wook Hwang; Akira Naganuma

doi:10.2131/jts.36.855

Toxicogenomics/proteomics Report

Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae

Tsutomu Takahashi, Shingo Nakashima, Takuro Masuda, Shigehiro Yoneda, Gi-Wook Hwang, Akira Naganuma

Author information

Keywords: Adriamycin, Resistance, Yeast, G1 cyclin, HMG-CoA synthase

JOURNAL FREE ACCESS

2011 Volume 36 Issue 6 Pages 855-857

DOI https://doi.org/10.2131/jts.36.855

Details

Abstract

To elucidate the mechanisms underlying adriamycin resistance, adriamycin resistance-related genes were explored using the budding yeast Saccharomyces cerevisiae as a useful eukaryotic model. The CLN1 and CLN2 genes, encoding G1 cyclin, and the ERG13 gene, encoding 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase, were identified.

Corresponding author

Register with J-STAGE for free!