The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Toxicomics Report
Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury
Gi-Wook HwangJin-Yong LeeMin-Seok KimMasayuki SatoTsutomu TakahashiAkira Naganuma
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2013 Volume 38 Issue 5 Pages 703-706

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Abstract

Metabolomic analysis was performed using the cerebellum of methylmercury-treated mice to elucidate the molecular mechanisms underlying methylmercury-induced cerebellar dysfunction. Methylmercury administration led to significant increases in the levels of 11 low molecular weight metabolites and significant reductions in the levels of 29 others, including several metabolites produced by amino acid and purine metabolism. Non-significant decreases in metabolites involved in the TCA cycle and in glutathione metabolism were also observed.

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© 2013 The Japanese Society of Toxicology
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