2013 Volume 38 Issue 5 Pages 703-706
Metabolomic analysis was performed using the cerebellum of methylmercury-treated mice to elucidate the molecular mechanisms underlying methylmercury-induced cerebellar dysfunction. Methylmercury administration led to significant increases in the levels of 11 low molecular weight metabolites and significant reductions in the levels of 29 others, including several metabolites produced by amino acid and purine metabolism. Non-significant decreases in metabolites involved in the TCA cycle and in glutathione metabolism were also observed.