The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Toxicomics Report
DNA microarray expression analysis of mouse kidney following cadmium exposure for 12 months
Maki TokumotoJin-Yong LeeYasuyuki FujiwaraMasahiko Satoh
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2013 Volume 38 Issue 5 Pages 799-802

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Abstract

Cadmium (Cd) is a toxic heavy metal and chronic exposure causes kidney injury. This study used DNA microarray analysis to examine gene expression in the kidney of mice chronically exposed to Cd. Female C57BL/6J mice were fed a 300 ppm Cd-containing diet or a control diet for 12 months. In comparison with control mice, the expression levels of 32 genes, including Hmox1 and Mt2, were elevated more than 2.0-fold, whereas 113 genes, including transport- and ubiquitination-related genes, were reduced less than 0.5-fold.

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© 2013 The Japanese Society of Toxicology
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