Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells

Ryo Nakano; Tsutomu Takahashi; Akira Naganuma; Gi-Wook Hwang

doi:10.2131/jts.38.821

Toxicomics Report

Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells

Ryo Nakano, Tsutomu Takahashi, Akira Naganuma, Gi-Wook Hwang

Author information

Keywords: HOXB13, Homeobox gene, Oxidative stress, Cytotoxicity

JOURNAL FREE ACCESS

2013 Volume 38 Issue 6 Pages 821-822

DOI https://doi.org/10.2131/jts.38.821

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Abstract

HEK293 cells transfected with a double-stranded siRNA to suppress expression of the homeobox gene HOXB13 were highly resistant to oxidative stress-inducing agents, such as hydrogen peroxide, N-ethylmaleimide (NEM), and paraquat. This finding suggests that HOXB13 might enhance cell injury caused by oxidative stress.

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