The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Letter
Garcinia vilersiana bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells
Yasuhiro ShinkaiIchiro YamanakaHo Huynh Thuy DuongNguyen Thi QuynhYasunori KanahoYoshito Kumagai
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2013 Volume 38 Issue 6 Pages 875-878

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Abstract

Garcinia vilersiana is a traditional medicinal plant in Vietnam. The petroleum ether extract of stem bark of Garcinia vilersiana (GVE) was prepared to evaluate its potential to activate Nrf2, a transcription factor of antioxidant and detoxifying enzymes. Exposure of mouse macrophage RAW264.7 cells to GVE (0.625-2.5 µg/ml) resulted in a significant activation of Nrf2, as evaluated by nuclear accumulation of this transcription factor, and increased antioxidant response element (ARE) binding activity in a time- and concentration-dependent manner. As a result, GVE caused ARE-dependent up-regulation of heme oxygenase-1 (HO-1) in the cells. These results suggest that GVE contains components that have the ability to activate the Nrf2/ARE/HO-1 signaling pathway, leading to cellular protection.

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© 2013 The Japanese Society of Toxicology
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