The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Letter
Global chemokine expression in methylmercury-treated mice: methylmercury induces brain-specific expression of CCL3 and CCL4
Min-Seok KimTsutomu TakahashiJin-Yong LeeGi-Wook HwangAkira Naganuma
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2013 Volume 38 Issue 6 Pages 925-929

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Abstract

We previously reported that methylmercury induces brain-specific upregulation of a chemokine gene, the CCL4 gene. In this study, we investigated the changes in gene expression levels of all chemokines in various tissues (cerebellum, cerebrum, kidney, liver, and spleen) of methylmercury-treated mice. We found that methylmercury induced upregulation of the CCL4 gene and the CCL3 gene, in a brain-specific manner. This finding suggests that upregulation of these two chemokine genes mediates selective damage by methylmercury in the central nervous system.

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© 2013 The Japanese Society of Toxicology
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