Gene expression analysis using DNA microarray in HK-2 human proximal tubular cells treated with cadmium

Jin-Yong Lee; Maki Tokumoto; Yasuyuki Fujiwara; Masahiko Satoh

doi:10.2131/jts.38.959

Toxicomics Report

Gene expression analysis using DNA microarray in HK-2 human proximal tubular cells treated with cadmium

Jin-Yong Lee, Maki Tokumoto, Yasuyuki Fujiwara, Masahiko Satoh

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Keywords: Cadmium, HK-2 cells, Renal toxicity, DNA microarray, Heat shock protein, Transcription factor

JOURNAL FREE ACCESS

2013 Volume 38 Issue 6 Pages 959-962

DOI https://doi.org/10.2131/jts.38.959

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Abstract

We examined the alteration of gene expression in HK-2 human proximal tubular cells exposed to cadmium (Cd) using DNA microarray analysis. Cd increased the expression of 30 genes, including 7 genes coding for heat shock proteins, more than 2.0-fold and decreased the expression of 21 genes, including transcription-related genes, such as AP2B1, HOXA7, HOXA9 and TCEB2, less than 0.5-fold prior to the appearance of cytotoxicity in HK-2 cells.

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