The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Toxicomics Report
Gene expression analysis using DNA microarray in HK-2 human proximal tubular cells treated with cadmium
Jin-Yong LeeMaki TokumotoYasuyuki FujiwaraMasahiko Satoh
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2013 Volume 38 Issue 6 Pages 959-962

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Abstract

We examined the alteration of gene expression in HK-2 human proximal tubular cells exposed to cadmium (Cd) using DNA microarray analysis. Cd increased the expression of 30 genes, including 7 genes coding for heat shock proteins, more than 2.0-fold and decreased the expression of 21 genes, including transcription-related genes, such as AP2B1, HOXA7, HOXA9 and TCEB2, less than 0.5-fold prior to the appearance of cytotoxicity in HK-2 cells.

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© 2013 The Japanese Society of Toxicology
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