Cell density-dependent modulation of perlecan synthesis by dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(II) in vascular endothelial cells

Takato Hara; Sayaka Sakamaki; Atsuya Ikeda; Takehiro Nakamura; Chika Yamamoto; Toshiyuki Kaji

doi:10.2131/jts.45.109

Letter

Cell density-dependent modulation of perlecan synthesis by dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(II) in vascular endothelial cells

Takato Hara, Sayaka Sakamaki, Atsuya Ikeda, Takehiro Nakamura, Chika Yamamoto, Toshiyuki Kaji

著者情報

キーワード: Bioorganometallics, Proteoglycan, Perlecan, Vascular endothelial cell, Zinc complex, 2,9-Dimethyl-1,10-phenathroline

ジャーナルフリー HTML

2020 年 45 巻 2 号 p. 109-115

DOI https://doi.org/10.2131/jts.45.109

詳細

抄録

Proteoglycans that are synthesized by vascular endothelial cells contribute to the proliferation, migration, and blood coagulation-fibrinolytic system in vascular endothelial cells. Clarification of the molecular mechanisms for proteoglycan synthesis allows understanding of the regulation of endothelial functions. The research strategy of bioorganometallics analyzes biological systems using organic-inorganic hybrid molecules as tools. The present study found dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(II) and its ligand-modulated perlecan expression in vascular endothelial cells, which depends on the cell density.

責任著者(Corresponding author)

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