LONG-TERM TOXICOLOGICAL STUDIES WITH MIZORIBINE (BREDININ^(R)) IN BEAGLE DOGS (THE SECOND REPORT) : PHTHOLOGICAL STUDIES ON VISCERAL ORGANS

Abstract

Four Beagle dogs were administrated with mizoribine 2.5 mg/kg/day for 36 months. Clinical and laboratory findings were fully described in the first report, in which no remarkable abnormalities were detected. Visceral organs of the experimental group and non-treated control group were submitted for pathological investigations. No conspicuous macroscopical and microscopical drug-induced changes were disclosed in the experimental group.