TERATOLOGICAL STUDY OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RABBITS

Noboru HOSHI; Koichi UENO; Takashi IGARASHI; Haruo KITAGAWA; Teruko FUJITA; Nobuo ICHIKAWA; Yuko KONDO; Masae ISODA

doi:10.2131/jts.10.SupplementII_227

Noboru HOSHI, Koichi UENO, Takashi IGARASHI, Haruo KITAGAWA, Teruko FUJITA, Nobuo ICHIKAWA, Yuko KONDO, Masae ISODA

Author information

Noboru HOSHI
Koichi UENO
Takashi IGARASHI
Haruo KITAGAWA
Teruko FUJITA
Nobuo ICHIKAWA
Yuko KONDO
Masae ISODA
Author's Organization：
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
Nippon Bio-Test Laboratories Inc.
Nippon Bio-Test Laboratories Inc.
Nippon Bio-Test Laboratories Inc.
Department of Pathology, Nippon Veterinary and Zootechnical College

Keywords: rabbit

JOURNAL FREE ACCESS

1985 Volume 10 Issue SupplementII Pages 227-234

DOI https://doi.org/10.2131/jts.10.SupplementII_227

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Abstract

A teratogical study was carried out in New Zealand White rabbits in order to examine the teratogenic potentiality of HPMCAS, a useful pharmaceutical excipient. HPMCAS was orally administered at dose levels of 625, 1, 250 and 2, 500 mg/kg/day for a period of 13 days from day 6 to day 18 of gestation. All pregnant females were sacrificed on day 29 of gestation and their fetuses were examined. The administration of HPMCAS during a period of organogenesis produced no embryotoxic and teratogenic effects as well as no influence on behavior, appearance and growth of animals.

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