BLOOD CLEARANCE OF <99m>Tc-PHYTATE FOR EVALUATION OF HEPATIC DYSFUNCTION IN RATS
Keywords:
carbon tetrachloride
1988 Volume 13 Issue 2 Pages 83-96
Details
1988 Volume 13 Issue 2 Pages 83-96
Organ distribution pattern, hepatic uptake ratio, and blood clearance were examined by giving <99m>Tc-phytate (<99m>Tc-P) to the normal rats. At the same time, the relation between the severity of hepatic function and blood clearance or hepatic uptake ratio of <99m>Tc-P was studied by using the rats with acute hepatic dysfunction experimentally induced by carbon tetrachloride (CCl4) administration. Furthermore, a comparative discussion on blood clearance test of <99m>Tc-P was made with serum transaminase test and with histological test of the liver. It appeared appropriate to administer <99m>Tc-P at the dose of 500μg/kg in order to obtain an effective blood clearance curve. A major part of <99m>Tc-p intravenously administered was take up into the liver, while the remainder of small amount into the spleen, kidneys, lung, and so on. Little was recognized in the thyroid gland. The hepatic uptake ratio of <99m>Tc-P reached the maximum 15 minutes after the administration. The disappearance rate of <99m>Tc-P from blood decreased with the increase in dose of CCl4 and with the passage of time after the CCl4 administration. The blood clearance test of <99m>Tc-P showed a sensitive reaction for the acute hepatic dysfunction induced by CCl4 equally to or higher than the serum transaminase test or histological test of the liver.
